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Olive Leaf Extract – Oleuropein: A Guide to Uses and Scientific Evidence

What is Olive Leaf Extract?

Olive Leaf Extract is derived from the leaves of the olive tree (Olea europaea), a plant native to the Mediterranean region. The extract contains various bioactive compounds, including polyphenols such as oleuropein, hydroxytyrosol, and tyrosol, which contribute to its health-promoting properties.

Uses of Olive Leaf Extract

Olive Leaf Extract is commonly used as a dietary supplement for various purposes, including:

  • Supporting cardiovascular health
  • Boosting immune function
  • Managing blood sugar levels
  • Protecting against oxidative stress
  • Supporting overall health and well-being

Scientific Support for its Uses

Olive Leaf Extract contains potent antioxidants, particularly oleuropein, which has been extensively studied for its health benefits. Antioxidants help neutralize free radicals in the body, reducing oxidative stress and inflammation, which are linked to various chronic diseases.

Research suggests that Olive Leaf Extract may support cardiovascular health by improving endothelial function, reducing blood pressure, and lowering cholesterol levels. Oleuropein has been shown to have vasodilatory effects, promoting blood flow and reducing the risk of cardiovascular events.

Furthermore, Olive Leaf Extract may boost immune function by enhancing the activity of immune cells and reducing the severity and duration of infections. Studies have demonstrated its antiviral, antibacterial, and antifungal properties, making it a promising natural remedy for immune support.

In addition, Olive Leaf Extract may help manage blood sugar levels by improving insulin sensitivity and reducing insulin resistance. Oleuropein and other polyphenols in the extract may enhance glucose uptake by cells, potentially benefiting individuals with diabetes or insulin resistance.

Moreover, Olive Leaf Extract exhibits neuroprotective effects and may protect against neurodegenerative diseases by reducing inflammation and oxidative damage in the brain. These properties contribute to its overall health-promoting effects and may support longevity and vitality.

Health Concerns

While Olive Leaf Extract is generally considered safe for most people when taken at recommended dosages, there are some potential health concerns to consider. High doses of Olive Leaf Extract may cause gastrointestinal upset, including nausea, diarrhea, or abdominal discomfort in sensitive individuals.

Additionally, individuals allergic to olive pollen or olive products may experience allergic reactions when consuming Olive Leaf Extract. It is important to consult with a healthcare professional before using Olive Leaf Extract supplements, especially for individuals with underlying health conditions or those taking medications.

Recommended Standardization or Dosage

Olive Leaf Extract supplements are available in various forms, including capsules, tablets, and liquid extracts. The recommended dosage of Olive Leaf Extract supplementation depends on individual factors such as age, weight, and health status.

For general health maintenance and antioxidant support, typical dosages of Olive Leaf Extract range from 500 mg to 1000 mg per day, standardized to contain 20-40% oleuropein. Higher dosages may be recommended for specific health conditions or under the guidance of a healthcare professional.


  1. Salehi B, Venditti A, Sharifi-Rad M, et al. The Therapeutic Potential of Oleuropein in the Treatment of Diabetes Mellitus and Its Complications. *Curr Med Chem*. 2018;25(23): diabetic complications.
  2. Qabaha K, Al-Rimawi F, Qasem A, Naser SA. Oleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extract. *J Med Food*. 2018;21(3):302-305. doi:10.1089/jmf.2017.0035
  3. Marrugat J, Covas MI, Fitó M, et al. Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation–a randomized controlled trial. *Eur J Nutr*. 2004;43(3):140-147. doi:10.1007/s00394-004-0457-7
  4. Brautigam C, Weinschütz T, Neuhaus G, Schmitz G. The heart protection effect of olive leaf extract is attenuated in isolated guinea pig hearts perfused with high glucose. *Eur J Nutr*. 2007;46(2):79-84. doi:10.1007/s00394-007-0641-0

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