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Calcium Pyruvate: A Guide to Uses and Scientific Evidence

What is Calcium Pyruvate?

Calcium pyruvate is a natural compound formed in the body during the metabolism of carbohydrates. It is the calcium salt of pyruvic acid and is commonly used as a dietary supplement for its potential health benefits.

Uses of Calcium Pyruvate

Calcium pyruvate is primarily used as a weight loss supplement and is often included in formulations aimed at enhancing fat metabolism and promoting weight loss. It is believed to stimulate the breakdown of fats and increase energy expenditure, potentially leading to greater calorie burn and weight loss. Additionally, some athletes use calcium pyruvate supplements to improve exercise performance and endurance.

Scientific Support for its Uses

While some studies suggest that calcium pyruvate supplementation may aid in weight loss by promoting fat breakdown and increasing energy expenditure, the evidence is limited and conflicting. A systematic review and meta-analysis published in the Journal of Obesity concluded that there is insufficient evidence to support the effectiveness of calcium pyruvate for weight loss[1]. More research is needed to determine its efficacy and safety in this regard.

Health Concerns

Despite its potential benefits, calcium pyruvate supplementation may pose some health concerns. High doses of pyruvate, the active component of calcium pyruvate, have been associated with gastrointestinal discomfort, including bloating, gas, and diarrhea. Additionally, long-term safety data are lacking, and the effects of prolonged supplementation are not well understood.

Recommended Dosage

The recommended dosage of calcium pyruvate varies depending on the specific health goal and individual factors such as age, weight, and overall health. However, typical dosages range from 1,000 mg to 3,000 mg per day, divided into two or three doses. It’s essential to start with a lower dosage and gradually increase it while monitoring for any adverse effects.


  1. Onakpoya IJ, Hunt K, Wider B, Ernst E. Pyruvate supplementation for weight loss: a systematic review and meta-analysis of randomized clinical trials. Journal of Obesity. 2014;2014:1-9. doi:10.1155/2014/706891
  2. Stanko RT, Reynolds HR, Hoyson R, Janosky JE, Wolf R. Pyruvate supplementation of a low-cholesterol, low-fat diet: effects on plasma lipid concentrations and body composition in hyperlipidemic patients. The American Journal of Clinical Nutrition. 1994;59(2):423-427. doi:10.1093/ajcn/59.2.423


Calcium pyruvate is a dietary supplement commonly used for weight loss and exercise performance enhancement. While some studies suggest potential benefits in promoting fat metabolism and increasing energy expenditure, the evidence is limited and conflicting. Moreover, calcium pyruvate supplementation may be associated with gastrointestinal discomfort, and its long-term safety is uncertain. Before starting any supplementation regimen, it’s crucial to consult with a healthcare professional, especially if you have underlying health conditions or are taking medication.

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