CoQ10 and Ubiquinol

Heart Failure 

Some research into the treatment of heart failure using CoQ10 has shown that it can noticeably decrease the following symptoms.  

• Fatigue 
  
• Muscle Pain 
  
• Weakness

More research still needs to be done, but people have reported improvement when taking this supplement for heart conditions. A 2020 study by the University of Naples in Italy reported that CoQ10 should be considered as a conventional alternative treatment for heart failure.  

Fertility 

There is some evidence provided by a 2018 study ran by the Chinese Ministry of Education that using Coenzyme Q10 to treat infertility in women can improve the rate of viable embryos in women with a medical history of poor ovarian response. They found that it was able to successfully counter oxidative stress for women using in vitro fertilization. The antioxidant properties can also improve fertility in as well by protecting sperm from damage caused by free radicals. Taking it also lowers the risk of sterility.  

Keep Your Skin Young 

This supplement is used in some topical creams for treating age-related skin conditions and countering free radicals. Research has shown that CoQ10 is most useful for increasing energy metabolism within the skin cells. This protects them from the potential damage of oxidative stress. Skin goes through a lot of stress because it is directly exposed to the environment, and this means that new cells are constantly needing to be made. The extra boost of energy provided by CoQ10 can speed up this process. 

Reduce Headaches 

 A 2016 study by Mashhad University of Medical Sciences in Iran found there was an over 50% decrease in headaches per month for participants who suffered from chronic headaches. They reported that CoQ10 could reduce the frequency, duration, and severity of headaches. There were also no side effects to taking the supplement. Similarly, a 2005 migraine study by the University Hospital Zurich in Switzerland agreed that there was a significant drop in instances of migraines among participants who used Coenzyme Q10 supplements to treat their condition.  

Help With Exercise Performance 

Various research studies have reported that CoQ10 can improve symptoms related to inflammation, including chronic inflammation from conditions like arthritis. This can also provide some relief from inflammation caused by working out or heavy exertion.  

Could Help With Diabetes 

There is some evidence that Coenzyme Q10 will counter a portion of the damage caused by oxidative stress and CoQ10 deficiencies. Increasing levels in people with Type 2 diabetes can strengthen cells and naturally protect the mitochondrial processes. This evidence was taken from several different studies, and more research needs to be done to find out more about how CoQ10 can positively affect diabetes. 

Might Play a Role in Cancer Prevention 

There is currently mixed information regarding the efficacy of CoQ10 in preventing the development of various cancers. It is a known antioxidant which means that it already minimizes the number of cells that are damaged by oxidation. The National Cancer Institute confirmed the mixed study results and determined that more research still needs to be done; however, there is anecdotal evidence in several studies that point towards CoQ10 aiding in treating several types of cancer, including pancreatic, prostate, lung, rectal, laryngeal, and colon. There are also some indications that taking this supplement will lower instances of cardiac toxicity for cancer patients. The effectiveness of using Coenzyme Q10 as a preventative measure is still unknown.  

Good for the Brain 

Pre-clinical trials reported by the College of Cornell University in 2008 have pointed toward CoQ10 as a potential treatment for numerous neurological conditions. Multiple universities are conducting studies to determine if cognitive decline can be halted, reversed, or slowed by using Coenzyme Q10. They know so far that it protects cells, improves energy production, and stops free radicals from damaging cells within the neuro system.   

Could Protect the Lungs 

A 1993 study by Osaka City University Medical School indicates that CoQ10 supplements can positively affect lung function for people suffering from chronic obstructive pulmonary disease (COPD). Their findings indicated that taking it could lower blood pressure and increase muscular energy metabolism. More research on CoQ10's effects is still needed to determine the full effect this product could have on people who have been diagnosed with lung conditions.   

Suggested Doses 

Because this compound is fat-soluble, CoQ10 will absorb easier if you eat food that has fat or oil before taking it. There are generally no side effects even for large amounts (e.g., up to 1,200 mg) when taken over a prolonged period of time. The body does not store this particular nutrient, so it needs to be replenished daily. You can take a Coenzyme Q10 supplement for up to 16 consecutive months. Follow your doctor's advice and any instructions that accompany the product for better results.  

Medication Interactions

There have been known cases of individuals on thyroid, diabetes, cancer, or blood thinner medications having reactions to CoQ10. Avoid taking Coenzyme Q10 without first consulting a medical professional if you are on or those types of medications. When in doubt, always reach out to a healthcare provider.  

What Foods Are High In Ubiquinol? 

You can add foods high in ubiquinol with a supplement to ensure that you get enough for your body's needs. The following foods are highest in ubiquinol.   

• Steaks
• Peanuts 
  
• Avocados 
  
• Soybean, canola, and olive oil 
  
• Sardines 
  
• Spinach 
  
• Chicken 
  

FAQs

How much CoQ10 ubiquinol should I take for fertility?

The United States National Library of Medicine has information on ongoing clinical trials tied to CoQ10 and its effect on fertility. So far, there have not been any conclusive results, but several previous studies seem to indicate that it can preserve the DNA and decrease instances of chromosomal abnormalities. The study listed that the participants were taking 600 mg doses a day for a prolonged period.

Coenzyme Q10 can aid in both male and female fertility by hampering oxidation stress within sperm and embryos. The amount of ubiquinol you should take is going to vary depending on the absorption rate. You will need to consult your doctor to determine the right amount for you based on diet, exercise, and current health status.  

Who should not take ubiquinol? 

For some people, this product can lower blood sugar and blood pressure. You should avoid taking this supplement before consulting a doctor if you have any of the following conditions.  

• Diabetes 
  
• Heart failure or a chronic heart condition
  
• Kidney disease or related conditions
• Liver disease or related conditions  
  
• If you are undergoing treatment for cancer 
  
• If you take blood thinners 
  

What medications should not be taken with CoQ10? 

Below is a list of specific medications that are known to have an adverse reaction to CoQ10. This is not exhaustive and may be subject to change, so if you are taking any medication, consult a medical professional before starting ubiquinol.  

• Medication to control hyperglycemia 
  
• Blood thinners like warfarin (Coumadin) or clopidogrel (Plavix) 
  
• Aspirin 
  
• Medication to control diabetes 
  
• Daunorubicin (Cerubidin) and doxorubicin (Adriamycin) or other medications meant to aid with chemotherapy
• Medication for blood pressure including diltiazem (Cardizem), nitroglycerin (Nitrostat or Nitrobid), metoprolol (Lopressor or Toprol), and enalapril (Vasotec) 
• Glaucoma medications like timolol drops (Betoptic) 
  
• Atorvastatin (Lipitor)
• Lovastatin (Mevacor) 
  
• Pravastatin (Pravachol) 
  
• Simvastatin (Zocor) 
  
• Gemfibrozil (Lopid) 
  
• Atenolol (Tenormin) 
  
• Labetalol (Normodyne)
• Metoprolol (Lopressor or Toprol) 
  
• Propranolol (Inderal) 
  
• Antidepressant medications such as imipramine (Tofranil), amitriptyline (Elavil), and doxepin (Sinequan)
  

Can ubiquinol raise blood pressure? 

CoQ10 and ubiquinol are known for lowering systolic blood pressure. A 2016 study by the University of British Columbia revealed that there is no definitive evidence that it can raise blood pressure. This is also not a side effect that has been seen during other studies featuring ubiquinol or other forms of Coenzyme Q10. If you would like to know more about how low blood pressure may affect your health, you can speak with your medical professional.  

What are the symptoms of a ubiquinol deficiency? 

CoQ10 is an essential nutrient that plays a large part in ensuring that your cells get the energy that they need. It has a large role in the health of the muscles, brain, and kidneys. That means when you are deficient, your cells are not getting enough energy or protection, and it can lead to damage. Some of the symptoms of ubiquinol deficiency include the following.  

• Muscle weakness
• Progressive muscle stiffness 
  
• Involuntary muscle contractions  
  
• Poor muscle tone  
  
• Seizures
• Cognitive issues 
  
• Abnormal eye movements 
  
• Hearing loss 
  
•  High blood pressure
  
• Blood in the urine 
  
• Reduction in white blood cell count 
  
• Frequent infections due to weakened immune system 
  
• Kidney failure 
  

There are some other symptoms that may be seen in certain cases or for individuals diagnosed with rare conditions. If you believe that you may be suffering from a CoQ10 deficiency or if you notice any of the symptoms listed above, contact your doctor.