Your Ultimate Guide to SAMe: How It Works, Why Should You Use It & When to Take It

Let's talk about SAMe. If you are not familiar with SAM-e (also known as S-Adenosylmethionine), it was first isolated in 1950s by an Italian researcher by the name of G.L Cantoni.

While it is used to treat a variety of conditions, SAM-e is recommended for those looking to promote improved moods, healthy joints, and optimal liver function.

This article covers the most frequently asked questions about SAMe to determine if this supplement would be beneficial to your daily lifestyle.

What is SAMe?

This naturally occurring amino acid can be found in virtually every living cell in the body and is responsible for more than 40 biochemical reactions.

SAMe is closely involved in the formation, activation, and breakdown of chemicals in the body including hormones, proteins, and lipids. It also contributes methylations reactions which are especially critical for brain chemicals and detoxification reactions.

Signs You May Need SAMe

People who don’t make enough SAMe naturally can show signs of deficiency. The amount of SAMe your body makes can be greatly impacted by age, illness, and diet. Common symptoms include:

  • Those suffering with low moods and depression
  • Those experiencing painful bone and joint discomfort
  • Those who have found excess bile in the liver

The Benefits of SAMe

The beneficial effects of SAMe supplementation are far-reaching due to the central role SAMe plays in so many metabolic processes. The four main benefits of include:


SAMe is considered one of the most effective natural antidepressants. This is due to its role in supporting healthy levels of serotonin and dopamine, two important neurotransmitters in the brain known for boosting moods.

Healthy levels of neurotransmitters in the brain helps combat generalized depression and anxiety. Clinical studies show SAMe can naturally restore a healthy mood in as little as 7 to 14 days when taken daily.*


In addition to boosting your mood, SAM-e can also help to improve joint function and mobility. It helps manufacture sulfur-containing compounds which are critical for joint tissue and cartilage. A deficiency if SAMe in our joint tissues inhibits the shock absorbing qualities that cartilage provides.

It also provides strong anti-inflammatory properties that reduce joint pain, stiffness, and swelling in the morning or after physical activity.


When your liver is damaged, you are unable to produce less SAMe. And without SAMe, your liver is unable to cleanse the body of harmful chemicals and toxins. This never-ending cycle makes supplementation increasingly important.

SAMe improves the utilization of glutathione, the body’s major detoxifier. This helps protect the liver from future damage while also improving the current condition of this vital organ.


SAMe may also be effective in treating the common symptoms associated with fibromyalgia such as chronic musculoskeletal pain, depression, fatigue, and morning stiffness.

There are numerous clinical studies showing SAM-e can be beneficial for patients suffering from fibromyalgia.* Improvements are noted by a significant reduction in the number of trigger points and painful areas as well as improvements in mood.

How Much Should I Take & When To Take It?

SAMe is shown to be absorbed more effectively when your stomach is empty so take this supplement daily before meals. And since one of the benefits is a mild boost of energy, we also recommend that you avoid taking SAMe late in the day to avoid sleep disruption.

We suggest starting with 200mg daily to see how your body responds. You can then increase after several days if needed. Based on individual results, 200mg to 800mg has been show to improve mood and reduce discomfort due to pain from osteoarthritis or fibromyalgia.

Anytime you add supplements to your diet, it is important to consult with your health care professional.

What Supplements Should I Take With SAMe?

It should be noted that vitamin B-12 and Folic Acid are needed to help the body provide adequate SAMe. Those using SAMe for depression in particular may want to consider adding vitamin B-12 and Folic Acid supplements.

SAMe vs. Prescriptions

There is evidence that shows SAMe may be just as effective as stronger medications, like antidepressants or ibuprofen. And since SAMe is very well tolerated with few side effects, it is an excellent natural alternative to addictive and costly prescriptions.

Why Choose Whole Health's Elemental SAMe?

We use Jarrow branded SAMe, made naturally by microbiological fermentation and then specially processed without chemical solvents. It is then manufactured under low temperature and low humidity to ensure a biologically active product.

While SAMe is one of the most versatile compounds in the world of supplements, it is also one of the most fragile. That’s why our enteric-coated tablets are individually cold glue blister packed to protect from moisture and degradation.

Whole Health’s Elemental SAMe is guaranteed 96% pure S-Adenosylmethionine to offer you the best in natural mood, joint, and liver support!

Shop Our Elemental SAMe Supplements Today!

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